A new generation of diet pills that
could achieve the same dramatic
weight loss as surgery could be
available within a decade.A team at University College London is working towards developing a weight loss pill that makes people feel they are full after eating a small amount of food.
Source: http://www.telegraph.co.uk
The stomach has to expand to digest food, the basic process by which the body harvests calories from meals, but scientists have found a way of stopping this from happening.
The pill could offer an alternative to stomach stapling - gastroplasty - in which a band or surgery is used to reduce the size of the stomach. This can result in weight loss of up to 7st in a year.
However, surgery can be risky with one in every 100 patients dying within 12 months. The potential new drug is described in the Journal of Pharmacology and Experimental Therapeutics by Dr Brian King and Dr Andrea Townsend-Nicholson.
“It is chemical gastric banding,” said Dr Townsend-Nicholson, adding that the pill could be available for use within five to 10 years.
The team found two proteins - P2Y1 and P2Y11 - which are receptors that pick up signals from nerves to control the size of the gut. These were identified in the guinea pig, but are also present in humans. Dr King said: “This would be a brand new approach to weight control.”
Dr Brian King says: “The mechanisms we have identified are important to the normal workings of the stomach - a hollow organ which actively relaxes to help accommodate the size of your meal.
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